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Faculty Profile Last Modified Time: 02:04:41 PM Wed, 19 May 2021   Contact Information Steven J. Ludtke Associated Profiles  Charles C. Bell Professor, Biochemistry & Molecular Biology, Director, CryoEM Core, Co-Director, Center for Computational and Integrative Biomedical Research (CIBR), Baylor College of Medicine   Mail Box: BCM125, BCM-Alkek Graduate School, Room No.: BCMN-N420    sludtke@bcm.edu     713-798-9020    Web Link    Lab Webpage    Imaging, Biophysics, Membranes, Structural Biology, Computational Biophysics    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   My group focuses on CryoEM/CryoET and quantitative image processing, applying these techniques to a wide range of biological systems ranging from individual macromolecules to whole cells. For the last 20 years my group has been developing the EMAN software suite for both high resolution single particle analysis as well as in-situ and in-vitro tomography. This software has been used on a large fraction of the structures in the EMDatabank, and with over 30,000 downloads is one of the most widely used in the field. In addition to developing new image processing methods such as deep learning applications and bispectral analysis, my group engages in a wide range of biological projects, from the high resolution structure and dynamics of individual molecules to the study of functioning macromolecular assemblies within the cell. Over the last 3-5 years, cryoEM has experienced a renaissance, largely due to the development of revolutionary direct detector technology, making this field directly competitive with X-ray crystallography for high resolution structural analysis, and providing many unique capabilities, such as in-situ structural biology. This is an exciting time for the cryoEM field, with many opportunities to substantially advance our fundamental understanding of biomolecular interactions.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Training Grants Houston Area Molecular Biophysics Training Program Computational Cancer Biology Training Program  Research Consortia GCC Cluster for Cellular and Molecular Biophysics  Appointments Title Department / School Institution Charles C. Bell Professor Biochemistry and Molecular Biology Baylor College of Medicine Director CryoEM Core Baylor College of Medicine

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