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Faculty Profile Last Modified Time: 05:10:02 PM Thu, 11 Jul 2024   Contact Information Olivier Lichtarge Associated Profiles  Professor, Cullen Chair, Molecular and Human Genetics, Cullen Foundation Chair and Director, Computational and Integrative Biomedical Research Center, Baylor College of Medicine   Mail Box: BCM225, One Baylor Plaza, Room No.: T921    lichtarge@bcm.edu     (713) 798-5646    Web Link    Lab Webpage    Evolution, Phylogenetics, Comparative Genomics, Molecular Evolution, Structural Bioinformatics and Structural Biology, Evolutionary Bioinformatics    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   Our lab marries computation with experiments to study the molecular evolution of genes and pathways. We seek to understand their functions, and how they may become corrupted by genetic mistakes or re-engineered to new ends. The long-term goals are to design new therapies and to harness the synthetic potential of organisms. Shorter term goals are to interpret the mutational action of human genome variations on health and disease. Our algorithms broadly merge mathematical and evolutionary principles. As a result, they enable multi-scale data integration and precise control of molecular functions. This has led to discoveries in diverse systems, for example, G protein signaling, malaria and cancer. Starting from structural bioinformatics, newer interests now include network theory, text-mining and cognitive computing. Technically, we draw upon a wide range of disciplines to address fundamental questions in structural biology, clinical genomics and precision medicine. Specific examples includes a network compression scheme that made tractable the diffusion of information across nearly 400 species. This approach uncovered a possible mechanism for the best current drug against malaria. Other network studies, reasoned over the entire PubMed literature to discover new kinases and protein interactions for p53. A distinct line of research quantifies the evolutionary action (EA) of mutations on fitness and bridges between molecular and population genetics. EA correlates with experimental loss of function in proteins; with morbidity and mortality in people; and with purifying gene selection in population. In head and neck cancer patients, EA stratifies outcomes and suggests alternate therapy for some patients. In the coming years we hope to unite these different approaches into a coherent path to precision therapy personalized to patients on a case by case basis.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia John S. Dunn GCC for Chemical Genomics  Training Grants NLM Training Program in Biomedical Informatics & Data Science for Predoctoral and Postdoctoral Fello Training Interdisciplinary Pharmacological Scientists  Appointments Title Department / School Institution Professor Molecular and Human Genetics Baylor College of Medicine

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