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Faculty Profile Last Modified Time: 09:40:27 AM Mon, 13 Apr 2020   Contact Information Richard Kulmacz Associated Profiles  Professor, Hematology, UT Health Science Center at Houston   Medical School Building, Room No.: 5.288    richard.j.kulmacz@uth.tmc.edu     713-500-6772    Web Link    Prostaglandin-Endoperoxide Synthases, Cyclooxygenase 1, Cyclooxygenase 2, Heme, Peroxidase, Hydrogen Peroxide, Peroxides, Arachidonic Acid    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   One of my lab's ongoing interests is the mammalian cytochrome b561 family of proteins. These are integral membrane hemoproteins that catalyze transmembrane transfer of an electron donated by ascorbic acid (Vitamin C). Our major focus at present is on CYBRD1, the b561 family member that is found in red blood cell membranes. Red cell CYBRD1 exports reducing equivalents from cytoplasmic ascorbate to recycle oxidized ascorbate in the blood plasma. This maintains blood antioxidant defenses and supports effective delivery of the multifunction vitamin to peripheral tissues. Patients with sickle cell disease often have low levels of plasma ascorbate and experience oxidative stress. We are collaborating with several UT hematologists in clinical studies to identify disruptions in the red cell CYBRD1 / ascorbate system in sickle patients, both to understand the pathological processes and to devise effective treatments.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Training Grants Houston Area Molecular Biophysics Training Program  Research Consortia GCC Cluster for Cellular and Molecular Biophysics  Appointments Title Department / School Institution Professor Hematology UT Health Science Center Houston

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