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Faculty Profile Last Modified Time: 11:36:26 AM Tue, 7 Apr 2020   Contact Information Vasanthi Jayaraman Associated Profiles  Professor, Biochemistry and Molecular Biology, UT Medical School at Houston   Medical School Building, Room No.: 6.174    Vasanthi.Jayaraman@uth.tmc.edu     713-500-6236    Web Link    Lab Webpage    Ligands, Glutamate Receptors, AMPA Receptors, Energy Transfer, N-Methyl-D-Aspartate Receptors, Glutamic Acid, Luminescence, Photolysis    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   Communication between nerve cells serves as the basis of all brain activity, and one of the fundamental steps involved in signal transmission between the nerve cells, is the conversion of a "chemical" signal liberated at the end of one nerve cell, into an "electrical" signal at the second nerve cell. This step is mediated by a class of membrane bound proteins known as ligand gated ion channels. Our laboratory is interested in gaining an understanding of how these proteins carry forward their function by being able to watch the movements of these proteins as they perform their function. This is achieved by using various cutting edge spectroscopic methods such as time resolved vibrational spectroscopy and single molecule fluorescence spectroscopy that allow the characterization of the dynamic state structure of the proteins. The structural changes thus determined are correlated to the functional consequences as measured by electrophysiological measurements. These investigations provide a detailed understanding of the agonist controlled function of the ligand gated ion channels and hence aid in the rational design of drugs targeting this group of important proteins that are involved in diverse neuropathologies, such as epilepsy and ischemia.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia John S. Dunn GCC for Chemical Genomics John S. Dunn, Sr. GCC for Magnetic Resonance  Training Grants Training Interdisciplinary Pharmacological Scientists Houston Area Molecular Biophysics Training Program  Research Consortia GCC Cluster for Cellular and Molecular Biophysics  Appointments Title Department / School Institution Professor Biochemistry and Molecular Biology UT Health Science Center Houston

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