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Faculty Profile Last Modified Time: 12:54:49 PM Fri, 22 May 2020   Contact Information Huey Huang Associated Profiles  Professor & Sam and Helen Worden Chair, Physics and Astronomy, Rice University   Mail Box: MS61    hwhuang@rice.edu     713-348-4899    Web Link    Soft-Matter Physics, Lipid Bilayer, Peptide Interactions, Membrane-Active Peptides, Oriented Circular Dichroism, X-Ray and Neutron In-Plane Scattering, Membrane Structures, Toroidal Pores, Membrane-Thinning Effect, Lipid Extracting Effect    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   Soft-Matter Physics: A lipid bilayer is a two-molecule-thick, flexible, two-dimensional fluid with many internal degrees of freedom. Peptide interactions can induce local structural changes in the bilayer. Elucidation of such structural changes and the associated energetics is the key for understanding the biological consequences of membrane-active peptides. Highlights of our research include developing the methods of oriented circular dichroism, X-ray and neutron in-plane scattering, anomalous diffraction for membrane structures and method of giant lipid vesicles with peptides. Highlights of our discoveries include the toroidal pores, membrane-thinning effect, lipid extracting effect, peptide orientation change in membranes, structure of the membrane fusion intermediate state stalk, structure of a pre-stalk intermediate state, crystal structures of barrel-stave pores and toroidal pores. Biology: The lipid bilayer of a cell membrane is the target of membrane-active peptides including antibiotics and beta-amyloid proteins. Peptide-membrane interactions are the mechanisms of several new structural classes of antibiotics and the key for understanding the amyloid diseases, including Alzheimer's and type II diabetes.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia The Gulf Coast Consortium for Bioinformatics GCC Consortium for Antimicrobial Resistance (GCC AMR)  Training Grants Nanobiology Interdisciplinary Graduate Training Program  Appointments Title Department / School Institution Professor & Sam and Helen Worden Chair Physics and Astronomy Rice University

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