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Faculty Profile Last Modified Time: 12:32:13 PM Wed, 10 Jul 2019   Contact Information Xiaodong Cheng Associated Profiles  Professor, Integrative Biology & Pharmacology, and Insitute of Molecular Medicine, UT Health Science Center at Houston   Medical School Building, Room No.: 4.212    xiaodong.cheng@uth.tmc.edu     713.500.7487    Web Link    Proteins, Cyclic AMP-Dependent Protein Kinases, Cyclic AMP, Protein Isoforms, Chemical Activation, Cyclic AMP Receptor Protein, Protein Kinases, Catalytic Domain    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   Our laboratory studies intracellular signaling associated with second messenger cAMP. We apply multidisciplinary approaches, coupling biochemistry, biophysics and cell biology with pharmacology and chemical biology, to understand the structure and function of exchange proteins directly activated by cAMP (EPAC). Our goals are to unravel the signaling intricacies of EPAC proteins and to design pathway specific probes for these important signaling molecules so that their functions can be pharmaceutically exploited and modulated for the treatment of human diseases. Our laboratory has developed first-in-class EPAC selective inhibitors and EPAC knockout mouse models to study the physiological functions and diseases relevance of this family of important signaling molecules. Recently, we have identified a potential use of EPAC inhibitors in the prevention and treatment of fatal rickettsioses. Currently, we are actively engaged in developing second generation isoform specific EPAC inhibitors and agonists and in exploring their potential uses in various human diseases including cancer, diabetes, chronic pain and infections.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Training Grants Houston Area Molecular Biophysics Training Program  Research Consortia GCC Cluster NanoX Gulf Coast Consortium for Translational Pain Research  Training Grants Training Interdisciplinary Pharmacological Scientists  Research Consortia GCC Cluster for Cellular and Molecular Biophysics  Training Grants The Cancer Therapeutics Training Program (CTTP)  Appointments Title Department / School Institution Professor Integrative Biology & Pharmacology UT Health Science Center Houston

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