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Faculty Profile Last Modified Time: 02:04:23 PM Wed, 19 May 2021   Contact Information James M. Briggs Associated Profiles  Professor, Biology and Biochemistry, NSM Associate Dean for Faculty Affairs, University of Houston   Houston Science Center, Room No.: 402D    jbriggs@uh.edu     (713) 743-8366    Web Link    Computer-Aided Molecular Design, Molecular Simulations, Protein Structure and Function, Inhibitor Design, Antiviral Drug Design, Antibacterial Drug Design, Biophysical Studies    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   Dr. James Briggs' research is focused in the highly interdisciplinary and collaborative area of computational chemistry/biochemistry. He develops and applies computational methods to problems of chemical and biochemical interest. His research falls into two general categories: computer-aided inhibitor design/discovery and computational biophysics. Briggs' main target areas in the inhibitor/ligand area are: Rho kinase 1 (heart disease), PTEN (cancer), PTEN/5HTC2C (addiction control), BCL2 (cancer), gluconeogenesis and glucose uptake (cancer); those for the computational biophysics area include cholera toxin, biofilm control, RNA structure prediction, protein electrostatics and pKa predictions, and identification of protein/enzyme function from structure only.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia John S. Dunn Gulf Coast Consortium for Chemical Genomics  Training Grants Houston Area Molecular Biophysics Training Program Computational Cancer Biology Training Program  Research Consortia Alcohol and Addiction Research Gulf Coast Cluster for Translational Addiction Science GCC Cluster for Cellular and Molecular Biophysics  Appointments Title Department / School Institution Professor Biology and Biochemistry University of Houston

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