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Faculty Profile Last Modified Time: 02:06:34 PM Wed, 19 May 2021   Contact Information Stanley J. Watowich Associated Profiles  Professor, Biochemistry and Molecular Biology, UT Medical Branch at Galveston   Mail Box: 0645, Basic Science Building, Room No.: 623    sjwatowi@utmb.edu     409-747-4749    Faculty Profile    Venezuelan Equine Encephalitis Viruses, Viruses, Alphavirus, Nucleocapsid, Dengue Virus, Nicotinamide N-Methyltransferase, Proteins, Aldehyde Reductase    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   My research focuses on understanding the molecular mechanisms of virus assembly and virus-host cell attachment, with particular attention to RNA enveloped viruses such as hepatitis C (HCV), Venezuelan equine encephalitis (VEE), and encephalitic flaviviruses. In addition, my laboratory has developed a novel cell-based pathogen-selected antipathogen technology to rapidly identify compounds that inhibit cytolytic pathogen replication. We have determined the structures of VEE virus assembly intermediates, and are utilizing this information to design novel antiviral agents that disrupt VEE virus assembly. We have developed an in vitro assembly system for HCV nucleocapsids, and are looking to use this technology to develop HCV vaccines and antivirals. We have developed technology to generate recombinant attachment domains of flavivirus envelope proteins, work that may aid vaccine development. Finally, we are seeking to apply our cell-based pathogen-selected antipathogen technology to discover compounds effective against foot-and-mouth disease, rickettsial infections, and hemorrhagic fever viruses, as well as VEE and HCV viruses.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia John S. Dunn GCC for Chemical Genomics  Training Grants Computational Cancer Biology Training Program  Research Consortia GCC Cluster for Cellular and Molecular Biophysics  Appointments Title Department / School Institution Professor Biochemistry and Molecular Biology UT Medical Branch at Galveston

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