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Faculty Profile Last Modified Time: 03:18:24 PM Thu, 24 Aug 2023   Contact Information Yousif Shamoo Associated Profiles  Ralph & Dorothy Looney Professor, BioSciences, Rice University   Keck Hall, Room No.: 335    shamoo@rice.edu     713-348-5493    Web Link    Lab Webpage    Structural Biology, Molecular Evolution, X-ray Crystallography, Microbial Evolution, Antibiotic Resistance    Associated Profiles Research and Expertise Affiliations  Research and Expertise Research Interests   Our interest in molecular evolution is stimulated by the rise in drug resistant pathogens and how understanding the physical basis for adaptation can be used for prediction of resistance and the identification of new targets and strategies for antimicrobial therapies. By combining approaches from biophysics and experimental evolution we are able to identify and characterize intermediates along the mutational pathways of adaptation and then link those intermediates to the overall evolutionary trajectory of the bacterial populations. Adaptive changes in protein sequence and expression impact organismal fitness and, consequently, dictate population dynamics. By combining experimental evolution with molecular biophysics we take a systems level view of adaptation and link it to the molecular mechanism responsible for the resulting evolutionary dynamics.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia John S. Dunn, Sr. GCC for Magnetic Resonance  Training Grants Houston Area Molecular Biophysics Training Program  Research Consortia GCC Consortium for Antimicrobial Resistance (GCC AMR) GCC Cluster for Cellular and Molecular Biophysics  Training Grants Training Program in Antimicrobial Resistance (TPAMR) Antimicrobial Resistance Training Program in the Texas Medical Center (AMR-TPT)

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