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Faculty Profile Last Modified Time: 09:02:36 AM Fri, 17 Apr 2020   Contact Information Ka-Yiu San Associated Profiles  E.D. Butcher Professor, Bioengineering and Chemical Engineering, Rice University   Mail Box: MS142, BioScience Research Collaborative, Room No.: 815    ksan@rice.edu     713-798-5361    Web Link    Lab Webpage    Cellular Function and Genotype, Genetic Engineering, HPLC, Metabolites, Cofactor Manipulations, Oxidation-Reduction Reactions, Escherichia Coli    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   San's Metabolic Engineering and Systems Biotechnology Laboratory has exploited several different molecular biology techniques to improve cellular properties and study the relation between cellular function and genotype. Characterization of genetically engineered strains is then performed with the use of bioreactors and analytical techniques such as HPLC are used to measure the metabolites produced. One of the most novel metabolic engineering tools developed in his lab, cofactor manipulations, has been used to investigate the importance of maintaining a proper balance of the biosynthetic transformations involving oxidation-reduction reactions in the cell. There are infinite applications of metabolic engineering in the medical and the industrial fields. Currently his group is investigating the following topics: Cofactor manipulations in Escherichia coli, Manipulation of NADH availability, Manipulation of CoA/acetyl-CoA availability, Biochemical pathway design and manipulation, Plant metabolic engineering, Quantitative systems biotechnology.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia John S. Dunn Gulf Coast Consortium for Chemical Genomics  Appointments Title Department / School Institution E.D. Butcher Professor Bioengineering Rice University

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