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Faculty Profile Last Modified Time: 12:13:18 PM Thu, 8 Dec 2022   Contact Information Krishna Rajarathnam Associated Profiles  Professor, Biochemistry & Molecular Biology, UT Medical Branch at Galveston   Mail Box: 1055, Medical Research Building, Room No.: 5.142    krrajara@utmb.edu     409-772-2238    Web Link    Chemokines, Interleukin-8, Glycosaminoglycans, Interleukin-8A Receptors, Interleukin-8B Receptors, Nuclear Magnetic Resonance, Dimers, Monomers    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   Our lab is interested in understanding the molecular mechanisms by which chemokines activate GPCR receptors and bind sulfated glycosaminoglycans (GAGs) to orchestrate in vivo leukocyte recruitment to the infected tissue and activate leukocytes for microbial killing at the target site. Precise spatiotemporal control of these processes is essential to mount an effective defense. Impaired recruitment and/or impaired activation will result in incomplete resolution, whereas uncontrolled recruitment and/or premature or sustained activation will result in destruction of healthy tissue and disease. It is now well established that most, if not all, chemokines exist as monomers and dimers, but the molecular mechanisms by which chemokines and monomer-dimer equilibrium mediate leukocyte function remain unknown. Using mouse models, cellular assays, and engineered monomers and dimers, we have shown that both monomers and dimers have differential activities and recruit neutrophils in a highly differential manner, that monomer-dimer equilibrium regulates recruitment, that monomers and dimers differentially bind in vivo GAGs, and that the role of GAG interactions is highly tissue-specific.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia John S. Dunn, Sr. GCC for Magnetic Resonance GCC Cluster for Cellular and Molecular Biophysics  Appointments Title Department / School Institution Professor Biochemistry and Molecular Biology UT Medical Branch at Galveston

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