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Faculty Profile Last Modified Time: 01:49:42 PM Fri, 22 May 2020   Contact Information B.V. Venkatar Prasad Associated Profiles  Professor, Biochemistry and Molecular Virology & Immunology, Alvin Romansky Chair in Biochemistry, Baylor College of Medicine   Mail Box: BCM125, BCM-Alkek Graduate School, Room No.: BCMN-N410    vprasad@bcm.edu     713-798-5686    Web Link    Lab Webpage    Protein Structure-Function & Folding, Virology, Biochemistry, Immunology, and Cell Biology of Viral & Microbial Pathogen, Glycobiology of Pathogen-Host Interactions, Cellular Antiviral Responses, Antiviral Drug Discovery/Design, Vaccine Strategies    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   Research in the Prasad Laboratory is focused on determining structure-function relationships in medically important viruses that are pathogens to humans and other animals. The current focus is on viruses that are causative agents of endemic severe diarrhea in humans. These viruses include rotavirus, calicivirus, and Norwalk virus. Rotavirus is the major pathogen of infantile gastroenteritis. More than a million children die every year worldwide because of rotaviral gastroenteritis. Recently, several other viruses, including calicivirus and Norwalk virus, also have been shown to be causative agents of pediatric diarrhea. Our three-dimensional structural analyses have provided architectural descriptions of these viruses. Our studies using monoclonal antibodies, reassortants, and baculovirus-expressed virus-like particles have provided insights into the molecular mechanisms of cell entry, infectivity, transcription, and assembly of rotavirus. Rotavirus is a member of the virus family Reoviridae. Comparative structural analysis of other members in this family, such as blue-tongue virus and aquareovirus, is being carried out to provide a unified picture of the molecular mechanisms underlying the morphogenesis and pathogenesis of these large, complex, multi-layered viruses. We perform our three-dimensional structural analyses by using electron cryomicroscopy and computer image-processing techniques. In favorable circumstances, x-ray crystallography is being used to study either entire virus particles or their protein components. We have recently determined the structure of Norwalk virus capsids to atomic resolution by using x-ray crystallographic techniques.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia John S. Dunn GCC for Chemical Genomics  Training Grants Training Interdisciplinary Pharmacological Scientists Houston Area Molecular Biophysics Training Program  Research Consortia GCC Consortium for Antimicrobial Resistance (GCC AMR) GCC Cluster for Cellular and Molecular Biophysics  Appointments Title Department / School Institution Professor Biochemistry and Molecular Virology & Immunology Baylor College of Medicine Alvin Romansky Chair Biochemistry Baylor College of Medicine

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