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Faculty Profile Last Modified Time: 12:12:25 PM Thu, 12 Sep 2024   Contact Information Gisela Camacho Hernandez Associated Profiles  Assistant Professor, Pharmacology and Toxicology, UT Medical Branch at Galveston     gicamach@utmb.edu    Web Link    Drug discovery and development, Medicinal Chemistry, Fluorescent probes    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year    Biopharmaceutical Chemistry Autonomous University of Baja California 2018  MS Biopharmaceutical Chemistry Autonomous University of Baja California 2013  BS Biopharmaceutical Chemistry Autonomous University of Baja California 2010  Research and Expertise Research Interests   Research InterestsOur broad research interests are centered on the development of novel small molecules as chemical tools and potential therapeutics, targeting selected transporters and ligand-gated ion channels (LGIC) that are associated with neuropsychiatric disorders. We are particularly interested in the monoamine transporters uptake 1 and 2, nicotinic acetylcholine receptors (nAChRs) and the glutamate N-methyl-D-aspartate (NMDA) receptor.Our approach, which requires collaborative efforts with other research groups, is divided into two branches: 1) drug discovery and development of potential therapeutics and 2) development of chemical probes.The drug discovery and development of potential therapeutics branch focuses on the design, synthesis, in vitro pharmacological characterization [e.g., radioligand binding assays, Förster resonance energy transfer (FRET)] and behavioral pharmacology of innovative ligands to generate structure-activity relationship (SAR) studies and lead optimization through off-target, pharmacokinetic and in silico screening. Additionally, it is envisioned that these compounds can also be used to study protein-ligand interactions by structural biology.The chemical probe branch focuses on the development of fluorescent cleavable and non-cleavable probes to study selected transporters and LGIC, ideally in their natural environment utilizing distinct microscopy techniques and flow cytometry.Together, the overall goal of our research efforts is by generating novel pharmacological tools, advance our understanding and connect from a molecular to behavioral level, the pathophysiology of neuropsychiatric disorders.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia Gulf Coast Consortium for Mental Health Research John S. Dunn Gulf Coast Consortium for Innovative Drug Discovery and Development Junior Faculty Network  Appointments Title Department / School Institution Assistant Professor Pharmacology and Toxicology UT Medical Branch at Galveston

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