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Faculty Profile Last Modified Time: 08:41:14 PM Fri, 15 Mar 2024   Contact Information Danh Truong Associated Profiles  Instructor, Sarcoma Medical Oncology, UT MD Anderson Cancer Center     dtruong4@mdanderson.org    Web Link   List of Publications    sarcoma, single-cell, spatial, differentiation, cancer    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Biomedical Engineering Arizona State University 2018  MS Biomedical Engineering University of Texas at Arlington 2014  BS Biology University of Texas at Arlington 2014  Research and Expertise Research Interests   I study bone and soft tissue sarcoma at MD Anderson Cancer Center. Given over 100 different sarcoma subtypes, my range of scope is narrowed to desmoplastic small round cell tumors, Ewing sarcoma, and liposarcoma. To that end, my approach has been to comprehensively characterize these disease entities through a multi-modal omics approach using single-cell/nucleus RNA- and/or ATAC-sequencing, spatial transcriptomics/proteomics. Second, we aim to dissect biology and tumor microenvironment and determine signatures or drivers of tumorigenesis that could enable therapeutic targeted therapies. Third, instead of systemic cytotoxic therapies, we aim to propose methods to repair cancer cells. I am developing a mesenchymal stem cell differentiation model to determine the regulators that promote differentiation toward osteoblasts, myoblasts, and adipocytes. My hypothesis is that studying the regulators of differentiation can help us infer and target the error in differentiation amongst different sarcomas with possible mesenchymal origins.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia Gulf Coast Cluster for Single Cell Omics Junior Faculty Network  Appointments Title Department / School Institution Instructor Sarcoma Medical Oncology UT MD Anderson Cancer Center

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