McRae, Ewan (Faculty Profile)

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Faculty Profile

Last Modified Time: 11:37:40 AM Tue, 6 Jun 2023

Contact Information
Ewan McRae	Associated Profiles
Assistant Professor, Center for RNA Therapeutics, Houston Methodist Research Institute


ekmcrae@houstonmethodist.org Web Link Lab Webpage
In Vitro Transcription, RNA Structure Design, RNA Biochemistry, Cell Biology, Cryogenic Electron Microscopy, Protein Purification

Professional Preparation
Research and Expertise
Affiliations
Appointments

Professional Preparation

Degree	Major	Institution	Year
PhD	Chemistry	University of Manitoba	2019
BS	Biochemistry	University of Manitoba	2014

Research and Expertise

Research Interests

The McRae lab works to combine structural and molecular biology and engineer structured RNA elements for application in RNA therapeutics. Thanks to recent advances in direct electron detector technology, vitrification, and reconstruction protocols, it is now possible to determine the structure of RNA species hitherto unapproachable. The method of choice for the structural determination of RNA that are too large for NMR and too dynamic to crystalize is cryogenic electron microscopy. Using the information from our cryo-EM studies we aim to better understand RNA-protein interactions and leverage this knowledge to improve the design of therapeutic RNAs, including mRNA therapies for cancer vaccines and treatments.

Publications/Creative Works

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Affiliations

Research Consortia

Gulf Coast Cluster for Cellular and Molecular Biophysics

Appointments

Title	Department / School	Institution
Assistant Professor	Center for RNA Therapeutics	Houston Methodist Research Institute

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