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Faculty Profile Last Modified Time: 11:20:02 AM Tue, 6 Jun 2023   Contact Information Yunfeng Chen Associated Profiles  Assistant Professor, Biochemistry & Molecular Biology, UT Medical Branch at Galveston     yunfchen@utmb.edu     409-772-0027    Web Link    Lab Webpage    integrin, platelet, mechanobiology, hemostasis and thrombosis    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Bioengineering Georgia Institute of Technology 2016  BS Theoretical and Applied Mechanics Peking University 2010  Research and Expertise Research Interests   "Mechano-medicine" is an emerging concept that tries to prevent and cure diseases by combining mechanobiology with biomedicine. The Chen lab focuses its research on the interface of mechanobiology, vascular biology and biomedicine. We use multidisciplinary approaches to 1) understand the mechanobiology of cells and molecules, including force-regulated molecular binding and conformational change, cell adhesion and mechano-signaling, in the vascular system; 2) shed light on the mechanobiology-related pathogenesis of vascular dysfunctions like thrombosis, atherosclerosis and cancer metastasis; and 3) eventually, develop mechanobiology-inspired therapeutics and research/diagnostic tools abiding the concept of ‘mechano-medicine’. The approaches of Chen lab can be summarized in seven M’s: Mechanics (investigating the mechanobiology of cell physiology and pathology); Microscopy (combining super-resolution imaging with force spectroscopy); Microfabrication (manufacturing microfluidic devices to realize high-throughput experimentation and develop mechanobiology-based diagnostic tools); Molecular engineering (designing and making protein mutants to understand disease pathology and explore potential therapeutic strategies); Molecular dynamics simulation (via collaboration, understanding the mechanisms underlying mechanobiological molecular behaviors); Mouse models (use transgenic mice to create disease models); and finally Mechano-medicine (designing and testing new therapeutics).  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia Gulf Coast Cluster for Cellular and Molecular Biophysics  Appointments Title Department / School Institution Assistant Professor Biochemistry & Molecular Biology UT Medical Branch at Galveston

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