Javascript must be enabled to use this form.

View Profile	Home Browse Faculty Facility Research Consortia Training Grants Courses Search Support About rSp Help and FAQ's Contact Us	GCC Home
Faculty Profile Last Modified Time: 02:12:41 PM Wed, 2 Jun 2021   Contact Information Praveen Rajendran Associated Profiles  Associate Professor, Center for Epigenetics & Disease Prevention, Institute of Biosciences and Technology -TAMHSC     prajendran@tamu.edu     713-677-7803    Web Link    Cancer Biology, Cell Culture, Apoptosis, Cancer Cell Line, Epigenetics, Phosphorylation, Safety Pharmacology, Toxicity Studies, Gene Expression, Cancer    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Pharmacology Birla Institute of Technology & Science 2006  B.Pharm Pharmacy Birla Institute of Technology & Science 1994  Research and Expertise Research Interests   Dr. Rajendran has a broad background in pharmacology with over 20 years of experience and a proven record of accomplishment in cancer chemoprevention, preclinical research, drug discovery & development. His research relates to identifying novel epigenetic approaches to the treatment and prevention of colorectal cancer, where most therapeutic options are woefully ineffective. He identified turnover of histone deacetylases (HDACs) triggering protein acetylation as a novel mechanism for cancer chemoprevention by dietary isothiocyanates. His lab routinely employs both cell-based and rodent animal models that made it possible to conduct clinical trials with dietary isothiocyanates, such as sulforaphane. In addition, he serves as the primary investigator in studies that test the hypothesis that isothiocyanates exploit HDAC turnover pathways, faulty DNA repair mechanisms, and genomic instability in cancer cells, leading to chemo-sensitization and the potential for enhanced cancer therapy. His expertise in working with NSAID-like drugs and dietary compounds combined with knowledge of histone and non-histone protein acetylation has resulted in collaborative efforts with GI clinicians at MD Anderson Cancer Center, DNA repair scientists at Methodist, proteomics experts at Baylor College of Medicine, plant circadian specialists at Rice University, and pharmacokinetic experts at the University of Houston. Praveen recently assumed leadership of the Antibody & Biopharmaceutics Core (ABC), a brand new service center focused on antibody engineering. As ABC Director, Praveen supports and advances the research mission of the IBT, maximize return on investment, and promote 'Team Science' at all levels. For more details, see https://ibt.tamhsc.edu/cores/abcore/index.html  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Training Grants The Cancer Therapeutics Training Program (CTTP)  Appointments Title Department / School Institution Associate Professor Center for Epigenetics & Disease Prevention Institute of Biosciences and Technology -TAMHSC

powering - The Partnership
Important Disclaimer: The responsibility for the accuracy of the information contained on these pages lies with the authors and user providing such information.