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Faculty Profile Last Modified Time: 01:23:08 PM Wed, 2 Jun 2021   Contact Information Mikhail Kolonin Associated Profiles  Professor and Director, Center for Metabolic and Degenerative Diseases, UT Health Science Center at Houston   Sarofim Research Building, Room No.: 430E    Mikhail.G.Kolonin@uth.tmc.edu     713-500-3146    Web Link    Cancer Progression in Obesity, Stem Cells, Adipose Tissues, Tumors, Effect of Adipose Stromal Cells on Cancer Progression    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Biology, Molecular Medicine Wayne State University 2000  MS   Novosibirsk State University    Research and Expertise Research Interests   Research in the Kolonin Laboratory converges on stem cells, obesity, and cancer. Specifically, the focus is on intercellular interactions in adipose tissues and tumors and the role of adult progenitor cells in pathology. These studies are based on the analysis of clinical specimens and mouse models. Dr. Kolonin and colleagues have discovered the phenomenon of adipose cell mobilization and trafficking to tumors and the stimulatory effect of adipose stromal cells on cancer progression. These findings have provided new insights on the association between obesity and cancer. The molecular mechanisms of adipose cell migration to tumors and their role in tumor microenvironment are under investigation. The group expertise in cell population separation and identification of tissue-specific cell surface receptors has led to the recent identification of delta-decorin as the first known marker selectively expressed on adipose progenitor cells. An agent designed to target adipose progenitor cells through binding to delta-decorin is being pre-clinically tested for long-term treatment of obesity and a combination cancer therapy. Other projects are focused on identification of molecules targeting brown adipose tissue for whole body imaging applications, adipose tissue engineering in three-dimensional culture, identification of liposarcoma-initiating cells, and exploring the role of adipose tissue in leukemia progression.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Training Grants The Cancer Therapeutics Training Program (CTTP)  Appointments Title Department / School Institution Professor and Director Center for Metabolic and Degenerative Diseases UT Health Science Center at Houston

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