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Faculty Profile Last Modified Time: 04:47:34 PM Thu, 20 May 2021   Contact Information Cliona Rooney Associated Profiles  Professor, Pediatrics, Hematology-Oncology Cell & Gene, Baylor College of Medicine     crooney@bcm.edu     832-824-4693    Web Link    Cytotoxic T-Lymphocytes, Adoptive Immunotherapy, Human Herpesvirus 4, T-Lymphocytes, Epstein-Barr Virus Infections    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD   University of Cambridge 1981  BSc   University of East Anglia 1978  Research and Expertise Research Interests   Dr. Cliona Rooney's research interests are immunotherapies for virus and non-virus-associated malignancies and diseases. In protocols developed with Dr. Helen Heslop, Dr. Malcolm Brenner, Dr. Stephen Gottschalk and Dr. Catherine Bollard, about 150 patients have received EBV or antigen-specific cytotoxic T-cells. These have prevented and cured Epstein-Barr virus-associated lymphoma in bone marrow transplant recipients produced mixed tumor responses, including complete remissions in patients with relapsed EBV-positive Hodgkin's disease and nasopharyngeal carcinoma and have produced clinical remission in chronic-active EBV infections. In the research laboratory, she is developing methods for the activation and expansion of antigen-specific CTLs for the treatment of non-viral cancers, investigating ways to render CTL resistant to immune evasion strategies used by tumor cells to grow in an immunocompetent host and developing means to induce antigen-specific tolerance.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Training Grants The Cancer Therapeutics Training Program (CTTP)  Research Consortia Gulf Coast Consortia Immunology Cluster  Appointments Title Department / School Institution Professor Pediatrics, Hematology-Oncology Cell & Gene Baylor College of Medicine

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