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Faculty Profile Last Modified Time: 10:56:28 AM Fri, 18 Jun 2021   Contact Information Wenshe Liu Associated Profiles  Professor, Chemistry, Texas A&M University   Chemistry Building, Room No.: 204    wliu@chem.tamu.edu     979-845-1746    Web Link    Lab Webpage    Organic Chemistry, Molecular Biology, Protein Evolution, Cell Biology, Bioorthogonal Reactions for Protein Modifications, Epigenetics, Phage Display, Protein FRET Labeling for Biosensor Development    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Chemistry University of California, Davis 2005  BS Chemistry Peking University 2000  Research and Expertise Research Interests   My laboratory is interested in the understanding of the epigenetic chromatin regulation by posttranslational histone modifications and the development of therapeutics that target chromatin epigenetics. The laboratory has two functional units: the biological unit and the chemical unit. In the four core histones of human chromatin exist a large variety of posttranslational modifications. These modifications regulate functions of chromatin by influencing its structure and interactions with transcriptional factors. To study regulatory roles of these posttranslational modifications in chromatin, the biological unit in the laboratory has been developing methods that combine both molecular biology and chemical biology to assemble chromatin with posttranslational modifications for cryo-EM structural studies and biochemical analysis of their interactions with epigenetic proteins. Active projects include chromatin dynamics influenced by lysine acetylation and lysine methylation, sirtuin and HDAC interactions with acetylated chromatin, LSD1-2 interactions with methylated chromatin, and histone acetyltransferase-catalyzed chromatin acetylation based on proteomic analysis. Since most epigenetic proteins including sirtuins, HDACs, histone demethylases, histone acetyltransferases, histone methyltransferases, and reader proteins for chromatin modifications are related to disease development in humans, the chemical unit in the laboratory is developing therapeutics that targeting these proteins for disease intervention. Approaches we have been employed include novel phage display techniques that have been developed in the laboratory and also small molecule synthesis that most researchers are using. Therapeutic targets we are actively pursue inhibitors for include SIRT1-3, HDAC1-11, LSD1-2, ENL, and BRD9.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Training Grants The Cancer Therapeutics Training Program (CTTP)  Research Consortia Gulf Coast Cluster for Cellular and Molecular Biophysics  Appointments Title Department / School Institution Professor Chemistry Texas A&M University

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