We are interested in the cellular and molecular pathways of microRNAs in inflammatory diseases. Our approach is multipronged and we work with genetically modified mice and clinical samples to decipher the mechanism of action of microRNAs. We have undertaken projects to delineate the function of miRNAs involved in adaptive and/or innate immunity (i.e. miR-155, miR-22), heart failure (i.e. miR-22), and lung COPD (i.e. miR-22). Currently, my research group, is dedicated to discovering the let-7 microRNA regulatory networks (targetomics) that contribute to chronic lung inflammatory disease(s). Our most recent work is exploring how the miRNA let-7 family functions in immune cells and lung stem cells to influence inflammation and lung injury in murine models of COPD and respiratory virus infection. A more recent funded project seeks to understand the role of let-7 as a direct regulator of IL6 and IL10 utilizing novel genetically modified mice. Our combined work highlights the importance of miRNAs in a wide-range human diseases and have potential implications in miRNA-based therapeutics.
Publications/Creative Works
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Affiliations
Research Consortia
Gulf Coast Consortia Immunology Cluster
Training Grants
Training in Precision Environmental Health Sciences (TPEHS)
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