Neilson, Joel (Faculty Profile)

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Faculty Profile

Last Modified Time: 01:51:04 PM Mon, 11 May 2020

Contact Information
Joel Neilson	Associated Profiles
Associate Professor, Molecular Physiology and Biophysics, Baylor College of Medicine


neilson@bcm.edu 713.798.8851 Web Link Lab Webpage
Post-Transcriptional Gene Regulation, Breast Cancer, Metastasis, Protein Translation, RNA-Binding Proteins, miRNA

Professional Preparation
Research and Expertise
Affiliations
Appointments

Professional Preparation

Degree	Major	Institution	Year
PhD		Stanford University	2004
BS		University of Washington	1996

Research and Expertise

Research Interests

The explosion of publicly available sequencing and transcriptional profiling data that lies essentially at the fingertips of the bioscience community has quite literally revolutionized both basic and clinical biological research. But the Neilson Laboratory believes that even with these resources, substantial gaps remain in scientific understanding of gene regulation and function. Our primary objective is to directly attack one of these gaps – to aid in building a better understanding of how programs of post-transcriptional gene regulation impinging on pre-existing mRNA impact mammalian development and disease. We are particularly interested in better defining how the 3' untranslated region of mRNA, and the factors that interact with this region (microRNAs and RNA binding proteins) ultimately control gene expression and function in mammalian systems. This mode of regulation is largely (and sometimes completely) invisible within the context of standard transcriptional profiling approaches.

The lab is currently focusing on several facets of this overarching topic. These range from prospective identification and mechanistic characterization of novel translational regulatory programs underlying classically defined "hallmarks" of human cancer to focused and directed testing of established models describing how post-transcriptional regulators interact with their targets.

Publications/Creative Works

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Affiliations

Research Consortia

Junior Faculty Network

Gulf Coast Consortia Immunology Cluster

Appointments

Title	Department / School	Institution
Associate Professor	Molecular Physiology and Biophysics	Baylor College of Medicine

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