The Inhalation Toxicology Core (ITC) Facility is designed to provide state-of-the-art capabilities for conducting exposures of experimental animals and in vitro models to smoke, gas and vapor phase environmental toxicants. The facility operates under the auspices of the UTMB Sealy Center for Environmental Health and Medicine and is funded, in part, by UTMB institutional commitments. It serves as an institutional service core that provides support to all UTMB investigators and students. In addition, the facility provides a foundation for inter-institution collaborative investigations. The costs to investigators for performing exposures are based on offsetting expenses for facility personnel, equipment maintenance and replacement, animal husbandry, supplies, etc. All exposure protocols must be approved by the UTMB Chemical Safety Committee. If animals are involved, protocols must also receive prior Inter/Intra Institutional IACUC approval.