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Faculty Profile Last Modified Time: 10:33:18 AM Tue, 21 Apr 2020   Contact Information Ricardo Rajsbaum Associated Profiles  Associate Professor, Microbiology and Immunology, UT Medical Branch at Galveston     rirajsba@utmb.edu     (409) 772-4917    Web Link    Innate Immunity, Virus Infection, Ubiquitin, Tripartite Motif Proteins, Antiviral, Influenza, Ebola, Zika, Dengue, West Nile Virus, Type-I Interferons, TRIM6    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD   MRC National Institute for Medical Research 2009  MSc   Weizmann Institute of Science 1999  BSc   Universidad Nacional Autonoma de Mexico 1996  Research and Expertise Research Interests   Work in the Rajsbaum laboratory focuses on the study of host-pathogen interactions and innate immune responses to viruses. Innate and cell-intrinsic immune responses are essential to protect host cells against pathogens. Members of the tripartite motif (TRIM) family of E3-ubiquitin ligases are involved in antiviral immunity by directly inhibiting viral replication or by sensing and transmitting signals to induce antiviral cytokines. However, to establish productive infection, viruses have developed sophisticated mechanisms to counteract host immune responses, including targeting TRIM proteins. Our lab is interested in elucidating the mechanisms by which TRIM proteins and other signaling molecules regulate antiviral functions and how viruses (Influenza, dengue, Zika, West Nile, Ebola, Nipah and other viruses) evade these immune responses. We and others have shown that members of the TRIM family (TRIM5, TRIM6, TRIM25) catalyze the synthesis of unanchored polyubiquitin chains that activate antiviral signaling pathways. In addition, new evidence indicates that TRIMs and ubiquitination of viral proteins can have both antiviral and proviral functions depending on the host environment. Our lab aims to dissect these molecular mechanisms that regulate virus replication using in vitro biochemical methods, primary immune cells, and in vivo animal models. We also hope to identify new components of innate immune signaling pathways and viral factors that could be targeted for therapeutic intervention.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia Gulf Coast Cluster for Immunology Junior Faculty Network  Appointments Title Department / School Institution Associate Professor Microbiology and Immunology UT Medical Branch at Galveston

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