Basic sciences: Discovery of novel G-protein coupled receptor targets in the treatment of cancer. Drug discovery for novel targets through high throughput screening and hits-to-lead optimization in the area of oncology. Development of unique humanized cellular platforms to test the efficacy of drugs in order to predict treatment outcomes in patients. Study of cellular signaling of proteins targeted by drugs to identify synergistic pathways and to understand mechanisms of resistance in order to design effective combination therapy in treatment of cancer. Clinical sciences: Identification of genetic, cellular, and circulating biomarkers to predict outcome of pharmacological treatment in cancer patients. Individualization of therapy using the information about target biology of drugs and genomics/proteomics of tumors to improve probability of achieving an objective response and improving survival.
Publications/Creative Works
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Affiliations
Research Consortia
Gulf Coast Cluster for Single Cell Omics
Appointments
Title
Department / School
Institution
Associate Professor
Pharmacy Practice and Translational Research, Pharmacology
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