The main theme of my work is to analyze phenotypic heterogeneity in bacterial cells and explore how this phenotypic heterogeneity impacts our health. Reversible drug tolerant phenotypes are thought to underlie the propensity of recurrent infections to relapse, and little is known about the physiology of these rare and transient sub- populations. Deeper understanding of the molecular make-up of these cell types will facilitate the development of therapeutics. Therefore, a major goal of my research is to study their physiology: the metabolite, RNA, protein, and regulatory content that allow them to tolerate extraordinary concentrations of drugs.
Publications/Creative Works
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