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Faculty Profile Last Modified Time: 09:28:16 AM Tue, 21 Apr 2020   Contact Information Yi Li Associated Profiles  Professor, Breast Center, Molecular & Cellular Biology, Molecular Virology & Microbiology, Baylor College of Medicine   Mail Box: BCM600, BCM-Alkek Graduate School, Room No.: BCMN-N1220    liyi@bcm.edu     (713) 798-3963    Web Link    Lab Webpage    Cancer Biology, Cell Signaling, Apoptosis, Cell Proliferation, Cancer Cell Biology, Cancer Biomarkers, Signal Transduction, Metastasis, Signaling Pathways, Cell Migration, Signaling, Cancer Metastasis, Oncogenes, WNT Signaling    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Microbiology Michigan State University 1996  MS Microbiology Yangzhou University 1987  BS Microbiology Yangzhou University 1984  Research and Expertise Research Interests   Dr. Li primarily studies breast cancer initiation and metastasis. He has made significant contributions to the field of breast cancer: his lab elucidated the ATM-p53-ARF-mediated anticancer barriers (apoptosis and senescence) during breast cancer initiation, identified a mammary biopotential progenitor population which is marked by cytokeratin 6, and discovered molecular mechanisms underlying the impact of pregnancy on breast cancer risk. Importantly, his lab succeeded in repositioning the FDA-approved anti-JAK inhibitor, ruxolitinib, for preventing breast cancer in preclinical mouse models, and a clinical trial based on this preclinical work is ongoing. As ruxolitinib is administered short-term or intermittently to induce apoptosis of precancerous cells, this treatment regimen overcomes a critical concern of currently used cancer prevention drugs (antiestrogens) which require prolonged treatment and can have significant side effects. His lab pioneered the use of the RCAS-TVA avian retroviral system for modeling breast cancer in mice (https://www.ncbi.nlm.nih.gov/pubmed/17090666). This method introduces genetic mutations into selected mammary cells (such as stem cells and specific progenitor cells) in the midst of normal cells in the mammary gland in mice at selected times. This method overcomes many of the shortcomings of existing rodent models and more closely mimics human breast cancer formation where only one or a few cells mutate to initiate the cancer development. His lab uses this unique method along with genetically engineered mouse models as well as human cell lines and patient tissue samples to investigate fundamental questions in breast cancer progression and cancer stem cells, as detailed in his lab webpage.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia Gulf Coast Cluster for Single Cell Omics  Appointments Title Department / School Institution Professor Breast Center, Molecular & Cellular Biology, Molecular Virology & Microbiology Baylor College of Medicine

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