Steroid hormones play a key regulatory role in many malignancies, including breast, prostate, and endometrial cancers, where they promote cell proliferation and survival. Steroid hormones Consequently, the estrogen receptor (ER), androgen receptor (AR), and progesterone receptor (PR) are validated therapeutic targets for breast, prostate, and endometrial cancer treatment, respectively. However, resistance to the available endocrine therapies develops frequently in these cancers, thus necessitating the development of better therapies. By utilizing genomic, cistromic, transcriptomic, and proteomic data to dissect the various functions of steroid receptors and their coregulators. In particular, we are interested in identifying epigenetic signatures that can be applied as biomarkers to predict disease aggressiveness and response to treatment. We are particularly focused on identifying novel gene targets that can be exploited therapeutically for the treatment of prostate cancer.
Publications/Creative Works
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Affiliations
Research Consortia
Gulf Coast Cluster for Single Cell Omics
Appointments
Title
Department / School
Institution
Associate Professor
Hematology & Oncology, Molecular and Cellular Biology
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