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Faculty Profile Last Modified Time: 10:38:41 AM Tue, 24 Mar 2020   Contact Information Daisuke Nakada Associated Profiles  Associate Professor, Molecular and Human Genetics, Baylor College of Medicine   Mail Box: BCM M225, One Baylor Plaza, Room No.: R713    nakada@bcm.edu     (713) 798-1175    Web Link    Lab Webpage    Hematopoietic Stem Cells, Neoplastic Stem Cells, Saccharomyces Cerevisiae Proteins, Leukemia, AMP-Activated Protein Kinases    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD   Nagoya University 2005  MS   Nagoya University 2003  BS   Nagoya University 2001  Research and Expertise Research Interests   The goal of our laboratory is to study the mechanisms that regulate hematopoietic stem cell (HSC) maintenance. The maintenance of many adult tissues depends upon stem cells that are capable of generating both differentiated cells and daughter stem cells. We study the mechanisms by which stem cells are maintained throughout life to better understand how tissue homeostasis is maintained, how tissue function deteriorate with age, and how we can harness stem cells for regenerative medicine. We recently discovered that female sex hormone estrogen stimulates HSC self-renewal and links physiological changes that occur during ovulation and pregnancy to HSC function. We are interested in revealing the molecular mechanism by which estrogen stimulates HSCs, and whether estrogen stimulation can be used to improve bone marrow transplant. We also study leukemias and the mechanisms by which they gain unlimited proliferation capacity. Many pathways that regulate stem cells are often hyper-activated to support indefinite proliferation of cancer cells. Similar to the hierarchical organization of normal tissues with tissue stem cells responsible for generating differentiated progenies, a subset of cancer cells called cancer stem cells (or cancer-initiating cells) exists in many cancer types, and these cells are postulated to be responsible for the maintenance of cancer, therapy resistance, and relapse. We are interested in understanding the mechanisms that regulate leukemia-initiating cells, and in particular how leukemia-initiating cells regulate metabolism and how this is different from normal hematopoietic progenitors. By studying stem cells and cancer that form in the same tissue in parallel, we hope to contribute to the development of novel cancer therapies that specifically target malignant cells without damaging our normal tissue.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia Gulf Coast Cluster for Single Cell Omics  Appointments Title Department / School Institution Associate Professor Molecular and Human Genetics Baylor College of Medicine

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