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Faculty Profile Last Modified Time: 10:57:03 AM Fri, 27 Mar 2020   Contact Information Marina Konopleva Associated Profiles  Professor, Frances King Black Endowed Professorship for Cancer Research, Deputy Department Chair, Leukemia, UT MD Anderson Cancer Center   MDA FC3.3048 (Unit 428)    mkonople@mdanderson.org     713.794.1628    Web Link    Acute Myeloid Leukemia, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Leukemia, Apoptosis, Myeloid Cells, Cytarabine, Bone Marrow, Therapeutics    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Experimental Hematology Federal Institute of Hematology and Blood Transfusion 1998  MD Medicine 1st Pavlov Medical Institute 1990  Research and Expertise Research Interests   My major interest is the regulation of apoptosis in normal and leukemic stem cells in the context of the bone marrow microenvironment. Our findings have indicated overexpression of the antiapoptotic genes Bcl-2 and Bcl-XL in quiescent leukemic cells but not in normal progenitor cells and the ability of bone marrow stromal cells induce Bcl-2 expression. We have explored strategies of sensitization to chemotherapy by inhibition of these genes, such as antisense oligonucleotides and small molecule inhibitors. We have further identified Raf/MEK/ERK and PI3K/AKT/ILK signaling pathways as pro-survival pathways abnormally activated in AML cells and are currently investigating the role of the leukemia microenvironment in the chemoresistance of leukemias mediated by activation of these pathways. Presently, my laboratory is interested in further delineating the role that bone marrow microenvironment plays in the chemoresistance of leukemic cells. We have demonstrated that interactions between stroma-secreted SDF-1 and CXCR4 prevent chemotherapy-induced apoptosis in CLL and in AML.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia Gulf Coast Cluster for Single Cell Omics  Appointments Title Department / School Institution Professor Leukemia UT MD Anderson Cancer Center

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