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Faculty Profile Last Modified Time: 11:57:05 AM Mon, 20 Apr 2020   Contact Information Kevin Morano Associated Profiles  Professor, Microbiology and Molecular Genetics, UT Health Science Center at Houston   MSB G420    kevin.a.morano@uth.tmc.edu     713-500-5890    Web Link    Heat Shock Response, Cellular Regulatory Systems, Protein Chaperone Function, Cell Growth, Cellular Adaptation, Environmental Stress, Saccharomyces Cerevisiae, Cancer, Anoxia, Amyloid Diseases, Prions, Triplet-Repeat Type Diseases    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  BS Biological Sciences University of California, Irvine 2000  PhD Microbiology University of California, Davis 1996  Research and Expertise Research Interests   The heat shock response is highly conserved in all kingdoms, making it one of the most ancient cellular regulatory systems. We have two primary interests, 1) how heat shock is sensed and transduced to yield a genome-wide transcriptional response, and 2) how protein chaperones, including the Hsp70, Hsp90 and the Hsp110 groups, function collaboratively within the cell during normal growth and during adaptation to environmental stress. The baker's yeast, Saccharomyces cerevisiae, is an ideal microbial model system in which to investigate these questions, due to its facile genetics, genomics and ease of manipulation. These studies will directly impact our understanding of how human cells respond to pathophysiological states such as cancer and anoxia which strongly induce a heat shock response. In addition, there is growing evidence that the amyloid diseases of protein misfolding, including prion-based maladies such as Creutzfeldt-Jakob (mad cow), and other triplet-repeat type diseases including Alzheimer's, Parkinson's, and Huntington's, are intimately linked to protein chaperone expression and function.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia GCC Cluster for Cellular and Molecular Biophysics  Appointments Title Department / School Institution Professor Microbiology and Molecular Genetics UT Health Science Center at Houston

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