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Faculty Profile Last Modified Time: 12:04:02 PM Mon, 20 Apr 2020   Contact Information Fen Wang Associated Profiles  Professor, Center for Translational Cancer Research, Institute of Biosciences and Technology -TAMHSC     wangfen@tamu.edu     713-677-7520    Web Link    Cell Signaling, Aberrant Cell Signaling, Birth Defects, Cancer, In Vitro Cell Culture Systems, In Vivo Mouse Models, FGF, Tyrosine Kinase, Metastasis    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Biochemistry Clarkson University/W. Alton Jones Cell Science Center 1994  MS Cell Biology Xiamen University    BS Microbiology Xiamen University    Research and Expertise Research Interests   The laboratory focuses on understanding the molecular basis of cell signaling, and how aberrant cell signaling leads to birth defects and causes cancers. Using in vitro cell culture systems and in vivo mouse models, we study how the fibroblast growth factor (FGF) activates its receptor (FF) tyrosine kinase, and how the activated FF transmits the signals to downstream targets and regulates proliferation, differentiation, homeostasis, and function of the cells, as well as in organogenesis and development, including prostate and cardiovascular system development. The laboratory also employs molecular biology, cell biology, and mouse genetic technologies to study how aberrant FGF signals promote tumor initiation, progression, and metastasis. In addition, how environmental factors contribute to tumorigenesis and congenital birth defects by modulating FGF signal intensity and specificity is also under the scope of our research interests.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia GCC Cluster for Cellular and Molecular Biophysics  Appointments Title Department / School Institution Professor Center for Translational Cancer Research Institute of Biosciences and Technology -TAMHSC

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