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Faculty Profile Last Modified Time: 01:36:33 PM Mon, 20 Apr 2020   Contact Information Matthieu G. Gagnon Associated Profiles  Assistant Professor, Microbiology and Immunology, UT Medical Branch at Galveston   Mail Box: 1019, MRB 4.104C    magagnon@utmb.edu     (409) 772-2326    Web Link    Ribosomes, Peptide Elongation Factors, Transfer RNA, Ribosomal RNA, Proteins, Proline, Peptides, Peptide Elongation Factor G    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Biochemistry University of Montreal 2009  MSc Biochemistry University of Montreal 2002  BSc Biochemistry University of Montreal 2000  Research and Expertise Research Interests   Work in the Gagnon laboratory is directed at understanding the structural basis of the functions of proteins and nucleic acids involved in gene expression, particularly translation. In all living cells, translation is mediated by a large macromolecular assembly, the ribosome. We are interested to characterize the mechanisms of regulation of protein synthesis mediated by ribosome-binding proteins, RNAs and small molecules, such as antibiotics. Understanding the mechanisms of protein synthesis in atomic details will lead to new antibiotic targets, which is particularly important nowadays with the increasing occurrence of bacterial resistance to antibiotics being one of the biggest threats to global health. More than half of clinically relevant antibiotics cure infections by inhibiting the bacterial ribosome, making the ribosome a validated drug target in the cell. Many pathogenic bacteria have acquired resistance mechanisms that rely on specialized ribosome-binding proteins capable of rescuing antibiotic-inhibited ribosomes. Rescue of protein synthesis allows pathogens to thrive in the presence of drugs. We are seeking to characterize the molecular mechanisms exploited by many human pathogens to rescue drug-inhibited ribosomes, making them resistant to commonly used antibiotics. To achieve these goals, our laboratory uses an integrated approach combining biochemical, biophysical, genomic, molecular genetics and structure determination techniques.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia GCC Cluster for Cellular and Molecular Biophysics  Training Grants Houston Area Molecular Biophysics Training Program Antimicrobial Resistance Training Program in the Texas Medical Center (AMR-TPT)  Appointments Title Department / School Institution Assistant Professor Microbiology and Immunology UT Medical Branch at Galveston

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