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Faculty Profile Last Modified Time: 11:32:15 AM Fri, 27 Mar 2020   Contact Information Zheng Sun Associated Profiles  Associate Professor, Medicine, Endocrinology, Diabetes and Metabolism, Molecular and Cellular Biology, Baylor College of Medicine   Mail Box: BCM185, Alkek Building, Room No.: ABBR-R616    zheng.sun@bcm.edu     (713) 798-3164    Web Link    Lab Webpage    Circadian Clock, Epigenomics, Nuclear Hormone Receptor, HDAC, Transcription Corepressor, Metabolism, Diabetes, Autism, Neurodegenerative Disease, Aging    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Pharmacology & Toxicology University of Arizona 2008  Research and Expertise Research Interests   What doesn't kill you makes you stronger. Hormesis, the paradoxical beneficial effect of low-dose stressors, can be elicited by reactive oxygen species (ROS), chemical carcinogens, calorie restriction, and physical exercise. Calorie restriction and exercise remodels redox homeostasis and energy metabolism, leading to amelioration of metabolic and neurodegenerative disorders, and extended lifespan. Thus, the beneficial effects of lifestyle management and the free radical theory of aging can be unified under the common conceptual framework of hormesis. Mechanistically, hormesis is attributed to epigenomic regulation of gene expression. We are interested in how the environment, including external dietary environment and physical exercise or internal hormonal environment and the circadian clock, regulates metabolism and cognitive functions at the epigenomic level. We use genetic animal models, recombinant viral vectors, molecular biology approaches such as epigenomics, metabolomics, physiology, and animal behavior tests.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Training Grants Training in Precision Environmental Health Sciences (TPEHS)  Research Consortia Gulf Coast Cluster for Single Cell Omics  Appointments Title Department / School Institution Associate Professor Medicine / Endocrinology, Diabetes and Metabolism Baylor College of Medicine Associate Professor Molecular and Cellular Biology Baylor College of Medicine

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