Our research program is aimed at developing chemical tools to understand the ubiquitin system (E1, E2, E3 enzymes, and DUBs) and autophagy for basic research and therapeutic purposes. The ubiquitin system and autophagy are evolutionarily conserved degradation systems that control protein/organelle function and quality. To this end, we study the mechanism of ubiquitin and autophagy enzymes, and then develop mechanism-based pharmacological probes to perturb the function of these enzymes. This allows us to uncover novel biological roles of these enzymes, to validate them as drug targets, and to initiate drug-discovery programs.
Publications/Creative Works
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