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Faculty Profile Last Modified Time: 07:33:59 AM Mon, 30 Mar 2020   Contact Information Noelle C. Anastasio Associated Profiles  Assistant Professor, Pharmacology & Toxicology, UT Medical Branch at Galveston     ncanasta@utmb.edu     (409) 772-9656    Web Link    Anastasio Laboratory    Serotonin Phencyclidine Cocaine Receptor, Serotonin, 5-HT2C Cues Impulsive Behavior N-Methyl-D-Aspartate Receptors Cocaine-Related Disorders Prefrontal Cortex Apoptosis Serotonin Receptors Recurrence Self Administration    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Pharmacology and Toxicology University of Texas Medical Branch 2009  MS Pharmacology and Toxicology University of Texas Medical Branch 2003  BA Biology University of Texas 2001  Research and Expertise Research Interests   My research interests lie at the interface of pharmacology, neuroscience, and psychiatry. Prevention and treatment of neuropsychiatric disorders could be greatly advanced by a more comprehensive understanding of the biology of impulsivity. Our group is focused on deciphering the patterns of individual differences in behavioral disinhibition and decision-making seen with respect to the development and maintenance of chronic neuropsychiatric disorders. In particular, we focus on glutamatergic neurotransmission and disinhibition of cortical top-down output in different facets of impulsive-compulsive traits. There is evidence that glutamate neurotransmission through the ionotropic glutamate N-methyl-D-aspartate receptor plays a key role in the cognitive and/or behavioral dimensions of impulsivity and addictive behaviors, perhaps within the corticostriatal circuit, a network integral to decision-making and goal-directed behavior. An additional focus of the laboratory is to determine that neuronal serotonin and glutamate systems mechanistically converge to govern impulsivity and that rebalancing these systems may ultimately support behavioral recovery in disorders marked by impulsivity concomitant with an imbalance in the reward system and reactivity to reward conditioned cues (e.g., psychostimulant addiction, binge-eating disorder, obesity).  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia GCC Cluster for Alcohol and Addiction Research GCC Mental Health Research Cluster Gulf Coast Cluster for Single Cell Omics  Appointments Title Department / School Institution Assistant Professor Pharmacology & Toxicology UT Medical Branch at Galveston

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