Javascript must be enabled to use this form.

View Profile	Home Browse Faculty Facility Research Consortia Training Grants Courses Search Support About rSp Help and FAQ's Contact Us	GCC Home
Faculty Profile Last Modified Time: 08:43:56 AM Mon, 30 Mar 2020   Contact Information Joydip Das Associated Profiles  Professor, Medicinal Chemistry, University of Houston     4849 Calhoun Road, Houston, TX 77204-5037     Health Building 2, University of Houston College of Pharmacy, Room No.: 7035    jdas@uh.edu     713-743-1708    Web Link    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Bio-organic Chemistry Indian Institute of Technology    MSc Organic Chemistry Univ. of Burdwan    Research and Expertise Research Interests   Molecular targets of ethanol in the brain: We are studying the actions of alcohol on the proteins involved in the presynaptic SNARE complex that regulates synaptic vesicle fusion and neurotransmitter release. Munc13-1 is one of such presynaptic active zone-protein implicated in modulating short-term presynaptic plasticity. We are looking at the effects of ethanol on the expression of this protein in in vitro cell culture and in vivo rodent models and how drinking can affect neurotransmitter release in different brain regions. The long-term goal of this project is to identify molecular targets of ethanol and design drug based on these targets. Development of subtype specific PKC activators/inhibitors: Protein Kinase C (PKC) is a serine threonine kinase that plays a central role in signal transduction, regulating divergent cellular functions. Aberrations in PKC signaling have been implicated in the development of multiple human diseases including several types of cancer, metabolic and cardiovascular complications of diabetes, central nervous system dysfunctions, neuronal degeneration and cardiovascular disorders and alcoholism. Our ongoing research aims at developing subtype specific activators/inhibitors leading to therapeutics. We are developing molecules based on simple chemical scaffold and testing their effects on subtype-specific PKC activities. To accomplish our goals, we use cell and molecular biology, protein biochemistry, histology, confocal microscopy, rodent brain micro-dissection, primary neuronal culture, X-ray crystallography, organic synthesis and molecular docking techniques.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia Alcohol and Addiction Research GCC Mental Health Research Cluster GCC Cluster for Cellular and Molecular Biophysics  Appointments Title Department / School Institution Professor Medicinal Chemistry University of Houston

powering - The Partnership
Important Disclaimer: The responsibility for the accuracy of the information contained on these pages lies with the authors and user providing such information.