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Faculty Profile Last Modified Time: 12:33:22 PM Fri, 27 Mar 2020   Contact Information Shao-Jun Tang Associated Profiles  Professor, Neuroscience & Cell Biology, UT Medical Branch at Galveston   Medical Research Building, Room No.: 2.104D    shtang@utmb.edu     (409) 772-1190    Web Link    Neuronal Plasticity, Chronic Pain, HIV-1, Pain, Wnt Signaling Pathway, N-Methyl-D-Aspartate Receptors, HIV, Neurons, Proteins, DNA, Hyperalgesia, Chromatin, Chromosomes, Homeobox Genes, Sirolimus, Hippocampus, Up-Regulation    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Molecular and Developmental Biology University of Toronto    MS Molecular Biology University of Toronto    Research and Expertise Research Interests   HIV-1 infection causes a spectrum of neurological/cognitive complications (NeuroAIDS), but the pathogenic mechanisms are poorly understood and effective therapies are not available. NeuroAIDS presents a huge opportunity for both basic and translational research. We are interested in the pathogenic processes that contribute to the development of NeuroAIDS. A focal point of our NIH-funded current research is on the HIV-associated pathological pain, a neurological complication suffered by many millions of HIV-1/AIDS patients. In collaboration with other investigators (including Dr. Ben Gelman and Sue Carlton at UTMB), we are working to elucidate the molecular, synaptic and glial mechanisms by which HIV-1 infection and the co-morbid factors (e.g. drugs of abuse and antiretroviral treatments) cause the pathological pain. In particular, we focus on the potential role of Wnt signaling in the pathogenesis. With the new knowledge generated, we aim to develop innovative therapeutics to treat the pain syndrome. We use interdisciplinary methodologies, including molecular biology, neuron imaging, gene knockout, electrophysiology and behavioral testing, in our studies on animal models, postmortem patient specimens and primary cultures of neurons and glia. Students/postdocs and other research scientists who are interested in joining the exciting projects are welcome to contact Dr. Tang (email: shtang@utmb.edu; Tel: 772-1190).  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia Gulf Coast Consortium for Translational Pain Research GCC Cluster for Alcohol and Addiction Research Gulf Coast Consortium for Translational Pain Research  Appointments Title Department / School Institution Professor Neuroscience & Cell Biology UT Medical Branch at Galveston

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