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Faculty Profile Last Modified Time: 10:15:01 AM Tue, 24 Jul 2018   Contact Information Julian Hurdle Associated Profiles  Professor, Center for Infectious and Inflammatory Diseases, Institute of Biosciences and Technology -TAMHSC, Director, IBT PhD Program     jhurdle@tamu.edu     713-677-7572    Web Link    Lab Webpage    Clostridium Difficile, Clostridium Infections, Anti-Bacterial Agents, Mupirocin, Structure-Activity Relationship, Mycobacterium Tuberculosis, Tuberculosis, Microbial Sensitivity Tests    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Molecular Microbiology University of Leeds 2005  BS Biology and Chemistry University of West Indies 2000  Research and Expertise Research Interests   Dr. Hurdle's research centers on the discovery of novel approaches to treat antibiotic-resistant infections and elucidating molecular and physiological responses of bacteria to antimicrobials. Hurdle's laboratory adopts a multi-disciplinary approach, involving: discovery of novel antimicrobials through phenotypic and enzyme-based screening of chemical libraries; characterizing the molecular action of novel antimicrobials; assessing antibiotic efficacy in animal models of disease; and interrogating the impact of genetic resistance on bacterial physiology and virulence. Notable achievements include the discovery of antimicrobial agents that are at various pre-clinical stages for treating Clostridium difficile infection, biofilm-mediated infections and Mycobacterium tuberculosis. A key concept from Hurdle's research is that the bacterial membrane is an Achilles of recalcitrant bacteria, such as stationary phase cells and biofilms; these cell types display phenotypic resistance and cause infections to relapse after treatment. Through this concept, we are probing mechanisms of chemically induced cell death in C. difficile.  We collaborate closely with medicinal chemists, structural biologists and pharmacologists, to achieve our goal of translating discoveries to human medicine.   Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia GCC Consortium for Antimicrobial Resistance (GCC AMR)  Training Grants Training Program in Antimicrobial Resistance (TPAMR) Molecular Basis of Infectious Diseases Training Grant Antimicrobial Resistance Training Program in the Texas Medical Center (AMR-TPT)  Appointments Title Department / School Institution Associate Professor Center for Infectious and Inflammatory Diseases Institute of Biosciences and Technology -TAMHSC

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