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Faculty Profile Last Modified Time: 10:50:08 AM Wed, 6 Jul 2016   Contact Information Seung-Hee Yoo Associated Profiles  Associate Professor, Dept of Biochemistry and Molecular Biology, UT Health Science Center at Houston   Medical School Building, Room No.: 6.178    Seung-Hee.Yoo@uth.tmc.edu     713-500-6136    Web Link    Lab Webpage    Circadian Rhythms, Mammals, Circadian Clocks    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Biological Sciences Korea Advanced Institute of Science and Technology 2004  MS Biological Sciences Korea Advanced Institute of Science and Technology 1997  BS Biological Sciences Ewha Women's University 1994  Research and Expertise Research Interests   In response to daily environmental changes imposed by Earth's rotation, almost all species, ranging from cyanobacteria to humans, have evolved physiological and behavioral rhythms, called circadian rhythms. Circadian rhythms are not passive responses to environmental changes; rather, they are driven by an active clock system, capable of anticipating changes and coordinating tissue specific function and generating systemic output responses. The harmony between our intrinsic biological timing and the daily environmental oscillation is critical to physiological well-being; conversely, disrupted circadian rhythms have been shown to cause or increase the risk of various chronic diseases. In our lab, we focus on delineating fundamental cellular mechanisms in circadian rhythms and also deciphering physiological and pathological roles of the clock. Our long-term goal is to translate such fundamental mechanistic knowledge into new drug targets and therapeutic strategies for improved prevention and treatment of chronic diseases. Currently, my lab are pursuing several projects, using an integrative approach combining mouse models with molecular and cellular mechanistic studies. In one project, we investigate the role of miRNAs in circadian clock regulation using a second-generation circadian reporter mouse line Per2::LucSV, with a particular focus on the mechanistic relationship between clock robustness and metabolic health. In another project, we investigate the role of a circadian E3 ligase in heart failure induced skeletal muscle atrophy using a novel transgenic mouse model. As part of the renowned lung research community at UTHealth, my lab is also actively investigating clock functions in chronic obstructive pulmonary disease. Armed with profound knowledge of the clock and broad experience in cutting-edge technologies, our research will advance our understanding of the molecular underpinnings of the clock and how best to exploit it for novel therapies against pressing human health concerns.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Training Grants Training Interdisciplinary Pharmacological Scientists  Appointments Title Department / School Institution Associate Professor Dept of Biochemistry and Molecular Biology UT Health Science Center at Houston

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