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Faculty Profile Last Modified Time: 07:42:15 AM Fri, 20 Jul 2018   Contact Information Jiusheng Yan Associated Profiles  Assistant Professor, Anesthesiology & Perioperative Medicine, UT MD Anderson Cancer Center   MDA Y6.5609, Room No.: Unit 110    jyan1@mdanderson.org     713.563.9179    Web Link    Lab Web Page    Large-Conductance Calcium-Activated Potassium Channels, Cytochrome B6f Complex, Photosynthesis, Heme, Spinacia Oleracea, Beta Carotene, Cytochromes B, Cyanobacteria    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Biochemistry & Molecular Biology Purdue University 2004  MS Botany Chinese Academy of Sciences 2000  BS Biology Wuhan University 1996  Research and Expertise Research Interests   The research in my laboratory is aimed at understanding structure, function and regulation of mammalian ion channels and exploring their therapeutic potential and application in treatment of pain, neurological diseases and cancer. Our current studies are focused on calcium-activated channels, such as the large-conductance, calcium and voltage-activated potassium (BK) channel.  With biochemical and electrophysiological approaches, we have identified a new family of ion channel regulatory proteins, designated as BK channel g-subunits. We are studying the regulatory mechanisms, and physiological and therapeutic relevance of these proteins. Additionally, we are keen in investigating the sensing and signaling complexes of ion channels at different structural levels from protein composition, posttranslational modifications to atomic structure in order to identify new ion channel proteins, regulatory mechanisms, and structural basis of ion channel function.  Ion channels have long been key therapeutic targets in disease intervention and pharmaceutical drug development. Our research is ultimately aimed at providing new knowledge and strategies in ion channel-targeted drug discovery and therapeutics.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia Gulf Coast Consortium for Translational Pain Research  Appointments Title Department / School Institution Assistant Professor Anesthesiology & Perioperative Medicine MD Anderson Cancer Center

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