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Faculty Profile Last Modified Time: 08:31:10 AM Fri, 20 Jul 2018   Contact Information Dorina Papageorgiou Associated Profiles  Assistant Professor, Translational Biology & Molecular Medicine, Electrical & Computer Engineering, Physical Medicine, Psychiatry and Behavioral Science, Baylor College of Medicine   Mail Box: BCM609, 7200 Cambridge St., 9th Floor    papageor@bcm.edu     (713) 798-7450    Web Link    Human Brain Neuroimaging, Real-Time Functional MRI Neurofeedback, Plasticity and Neuro-Rehabilitation of Cortical Blindness, Neuro-Rehabilitation of Speech Impairment, Neuro-Rehabilitation of Chronic Pain    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Biological Sciences UT MD Anderson Cancer Center    MHSc Psychiatric Epidemiology Johns Hopkins University, Bloomberg School of Public Health    BA Psychology and Sociology University of Georgia    Research and Expertise Research Interests   The areas of focus of my laboratory - Investigational Targeted Brain Neuro-therapeutics - funded by the McNair Medical Institute, include the neuro-rehabilitation of: visual cortical blindness; speech/motor impairment; and chronic pain as a result of traumatic brain injury, stroke, brain tumor, neurodegenerative disease, and pain syndromes. We use a novel intervention to provide cortically targeted neuro-rehabilitation, called real-time functional MRI neurofeedback to induce reorganization in cortical and subcortical pathways. Patients undergo rneurofeedback in real time to upregulate or downregulate the activity of intact cortical and/or subcortical areas in conjunction with the continuous presentation of visual stimuli inside the MRI environment with the goal to restore or reorganize lesioned pathways associated with vision, speech, or pain. The modulation in the Blood-Oxygen-Level-Dependent (BOLD) signal intensity is achieved by feeding\" back to the patient the magnitude of mean BOLD signal intensity of his/her intact cortical area during the presentation of a stimulus in real-time. The hypothesis is that such training engages Hebbian mechanisms that modulate the activity of intact cortical areas with the goal to improve performance. The current research goals of my laboratory are: To examine and understand the neural mechanisms of brain plasticity in the design of treatments that will enhance nervous system recovery after a brain insult; To achieve long-term effects of personalized neurofeedback interventions at targeted cortical and subcortical areas, and; To optimize rt-fMRI neurofeedback as \"a next generation\" neurotherapeutic approach with the end goal to use this tool in the clinical setting, the effects of which can be translated outside the MRI environment. The long-term goal is to correlate neuroimaging with genetic biomarkers to better understand the pathways and mechanisms involved in the dynamic variability in disease risk and brain reorganization, which will allow us to induce fast, robust and long-term brain neuro-rehabilitation.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia Gulf Coast Cluster for NeuroEngineering Gulf Coast Consortium for Translational Pain Research  Appointments Title Department / School Institution Assistant Professor Translational Biology & Molecular Medicine Baylor College of Medicine

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