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Faculty Profile Last Modified Time: 11:41:33 AM Fri, 27 Mar 2020   Contact Information Yongcheng Song Associated Profiles  Professor, Pharmacology and Chemical Biology, Baylor College of Medicine   Mail Box: BCM330, One Baylor Plaza, Room No.: 520.08    ysong@bcm.edu     713-798-7415    Web Link    Methyltransferases, Aldose-Ketose Isomerases, Enzyme Inhibitors, Isocitrate Dehydrogenase, Lysine    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD   National University of Singapore 2000  Research and Expertise Research Interests   We are interested in discovery and development of novel small molecule inhibitors of biologically important proteins, targeting cancer and infectious diseases. These compounds will be used as chemical probes to find new cancer biology (Chemical Biology), or further developed to become clinically useful drugs (Drug Discovery). These goals will be achieved by using a combination of rational, computational drug design, synthetic chemistry, protein x-ray crystallography, high-throughput screening, biological activity testing, and molecular & cell biology. Our currently active projects include: 1. Novel chemical probes targeting epigenetic (histone/DNA modification) proteins: We have recently discovered novel inhibitors of histone H3-lysine79 (H3K79) methyltransferase DOT1L, H3K4 demethylase LSD1, and histone acetyltransferase p300/CBP. These compounds were found to have selective activity against MLL-rearranged leukemia and other cancers. We are actively exploring functions of several other epigenetic proteins in cancer, designing and synthesizing potent and selective inhibitors as potential therapeutics. 2. Drug discovery targeting Zika and Dengue viruses, which are important human pathogens. Through compound screening followed by medicinal chemistry, a novel series of compounds were identified, for the first time, to be potent and drug-like inhibitors of Zika and Dengue virus proteases. These compounds exhibited potent in vitro and in vivo antiviral activity. Optimization of activity as well as drug properties is on-going, in an effort to find drug candidates to prevent and treat Zika and Dengue infections. 3. Chemical probes targeting cancer-associated gene mutations: Genetic studies show that a high frequency of IDH (isocitrate dehydrogenase) mutation was identified in glioma (75%), AML (20%) and other types of cancer. Biochemical studies as well as clinical evidence suggest IDH mutation plays important roles in cancer initiation and/or progression. We are using a combination of chemical, biophysical and molecule & cell biology methods to develop novel chemical probes targeting IDH mutation and investigate cancer biology of mutant IDH.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Training Grants Training Interdisciplinary Pharmacological Scientists  Research Consortia GCC Cluster for Cellular and Molecular Biophysics  Training Grants The Cancer Therapeutics Training Program (CTTP)  Appointments Title Department / School Institution Professor Pharmacology Baylor College of Medicine

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