Javascript must be enabled to use this form.

View Profile	Home Browse Faculty Facility Research Consortia Training Grants Courses Search Support About rSp Help and FAQ's Contact Us	GCC Home
Faculty Profile Last Modified Time: 12:54:11 PM Thu, 7 Mar 2024   Contact Information Peggy Goodell Associated Profiles  Professor and Chair, Stem Cells and Regenerative Medicine Center (STaR), Vivian L. Smith Chair in Regenerative Medicine, Baylor College of Medicine   One Baylor Plaza, Room No.: N1030    goodell@bcm.edu     (713) 798-1265    Web Link    Lab Webpage    Hematopoietic Stem Cells, DNA (Cytosine-5-)-Methyltransferase, Hematopoiesis, Bone Marrow Cells, Cell Separation    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD   University of Cambridge 1991  BS   Imperial College 1986  Research and Expertise Research Interests   The focus of the Goodell Lab is the basic mechanisms that regulate hematopoietic stem cells, and how their misregulation leads to leukemia development. Stem cells reside in the bone marrow in a quiescent state, but rapidly become activated to regenerate the hematopoietic system. We are studying several genes involved in different aspects of stem cell activation, including some that transduce initial signals, and others that regulate self-renewal and differentiation. This work has led us to study the effects of stress, such as infection or age, on hematopoietic stem cells, using gene expression profiling to examine the changes that occur in mouse stem cells over time. We are also studying the role of epigenetic modifications, such as DNA methylation, on hematopoietic stem cell (HSC) function and biology. In particular, the lab is investigating the role of DNA methyltransferase 3a (DNMT3A) in regulating stem cell function, and how mutations in DNMT3A lead to age-related clonal hematopoiesis and development of hematologic malignancies.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia Gulf Coast Cluster for Regenerative Medicine Gulf Coast Cluster for Single Cell Omics Gulf Coast Consortia Immunology Cluster  Appointments Title Department / School Institution Professor and Director Stem Cells and Regenerative Medicine Center (STaR) Baylor College of Medicine

powering - The Partnership
Important Disclaimer: The responsibility for the accuracy of the information contained on these pages lies with the authors and user providing such information.