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Faculty Profile Last Modified Time: 09:40:15 AM Wed, 1 Apr 2020   Contact Information Rebecca Berdeaux Associated Profiles  Associate Professor, Integrative Biology and Pharmacology, UT Health Science Center at Houston   Medical School Extension, Room No.: R366    rebecca.berdeaux@uth.tmc.edu     713.500.5653    Web Link    Lab Webpage    Skeletal Muscle, Cyclic AMP Response Element-Binding Protein, Muscle Development, Regeneration, Response Elements, Obesity, Muscles, Phosphotransferases    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD Molecular and Cell Biology University of California at Berkeley 2003  BS Biology University of Illinois, Urbana-Champaign 1997  Research and Expertise Research Interests   Most mammalian tissues are highly adaptive to changing physiological states. Extracellular cues or signals not only prompt immediate adjustments within cells in seconds or minutes, but also frequently initiate longer-term responses through induction or repression of gene expression. Signal-dependent transcription is a particularly important means by which metabolically active tissues adapt to changing nutrient availability, physical demands and even acute tissue damage. Our laboratory studies one such transcriptional pathway activated by hormonal signaling through the second messenger cAMP to the transcription factor CREB. One of the genes induced by CREB in many tissues is a serine/ threonine kinase called SIK1 (salt inducible kinase 1). SIK1, in turn, either feeds back to inhibit CREB or feeds forward to promote activity of other transcription factors, such as the myocyte enhancer factor MEF2. We hypothesize that SIK1 is temporally regulated by transcriptional and post-translational mechanisms to allow appropriate physiologic responses in liver and skeletal muscle. Moreover, we posit that dysregulated SIK1 activity could contribute to pathophysiologic states including type 2 diabetes and muscle damage after injury or during aging. Using biochemical approaches and mouse genetics, we are currently investigating regulation and function of SIK1 in both organ systems, with an aim of better defining general and tissue-selective mechanisms of SIK1 regulation in vivo. Located within the thriving Texas Medical Center, our laboratory and department are equipped with state-of-the art instrumentation for phenotypic analysis of mice and tissues, confocal microscopy, in vivo bioluminescence reporter imaging in mice, and biochemical assays of cellular signaling. We study cell signaling in primary hepatocytes and myoblasts and develop unique transgenic mouse models to rigorously test our hypotheses.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia Gulf Coast Cluster for Regenerative Medicine GCC Cluster for Cellular and Molecular Biophysics  Appointments Title Department / School Institution Associate Professor Integrative Biology and Pharmacology UT Health Science Center Houston

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