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Faculty Profile Last Modified Time: 10:38:46 AM Mon, 23 Jul 2018   Contact Information Jose Onuchic Associated Profiles  Harry C and Olga K Wiess Chair of Physics, Professor, Chemistry and BioSciences, Rice University   Brockman Hall, Room No.: 110    jonuchic@rice.edu     713-348-4197    Web Link    Lab Webpage    Life Chemistry, Theory & Computation    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD   California Institute of Technology 1987  Research and Expertise Research   JOSE ONUCHIC has led the biological physics community as it attempts to devise an integrated picture of a variety of model biochemical and biological systems. His research has expanded across the scales of molecular-level interactions to cellular systems to organized multi-cellular structures. At Rice he will move this view towards medical applications focusing on cancer. In protein folding, he has introduced the concept of protein folding funnels as a mechanism for the folding of proteins. Convergent kinetic pathways, or folding funnels, guide folding to a unique, stable, native conformation. Energy landscape theory and the funnel concept provide the theoretical framework needed to pose and to address the questions of protein folding and function mechanisms. He also works on theory of chemical reactions in condensed matter with emphasis on biological electron transfer. He is also interested in stochastic effects in gene networks with connections to bacteria decision-making and cancer.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Training Grants Houston Area Molecular Biophysics Training Program Computational Cancer Biology Training Program Houston Area Molecular Biophysics Training Program  Appointments Title Department / School Institution Professor Chemistry and BioSciences Rice University Harry C and Olga K Wiess Chair Physics Rice University

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