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Faculty Profile Last Modified Time: 11:03:13 AM Thu, 17 Nov 2011   Contact Information Zhiqiang An Associated Profiles  Professor and Director, Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, UT Health Science Center at Houston   Sarofim Research Building, Room No.: 532    zhiqiang.an@uth.tmc.edu     713.500.3011    Web Link    Fungi, Antibodies, Monoclonal Antibodies, Echinocandins, Endophytes, Neoplasms, Mycorrhizal Fungi, Fungal Communities    Associated Profiles Professional Preparation Research and Expertise Affiliations Appointments  Professional Preparation  Degree Major Institution Year  PhD   University of Kentucky 1991  Research and Expertise Research Interests   Dr. An's group focuses on the discovery and development of therapeutic antibodies and antibiotics against human diseases including cancer and infectious diseases. Currently, we have five major research areas. 1) cancer drug resistance mechanisms in the human epidermal growth factor receptor (HER/ErbB) signaling pathways using monoclonal antibodies as platform technology; 2) the interactions between proteases and anti-tumor antibodies in the tumor microenvironment to delineate the roles of proteases play in tumor resistance to antibody immune therapies; 3) biomarkers for therapeutic monoclonal antibodies targeting the HER/ErbB signaling pathways; 4) high throughput technologies for cloning and characterization of antibodies from animals and humans in response to experimental vaccines, and 5) Pnemocandin biosynthesis and biocombinatorial chemistry approach for natural products drug discovery. In addition to the research projects, Dr. An's team has established a comprehensive antibody drug discovery platform with a focus on antibody lead optimization technologies such as antibody phage display, deep sequencing of antibody encoding genes from individual antibody expressing B cells, affinity maturation and humanization.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia GCC Cluster NanoX Gulf Coast Consortia Immunology Cluster  Training Grants The Cancer Therapeutics Training Program (CTTP) Training Interdisciplinary Pharmacology Scientists  Appointments Title Department / School Institution Professor and Director Texas Therapeutics Institute UT Health Science Center Houston

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