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Faculty Profile Last Modified Time: 01:27:36 PM Tue, 7 Apr 2020   Contact Information Thomas Green Associated Profiles  Associate Professor, Pharmacology & Toxicology, UT Medical Branch at Galveston     thgreen@utmb.edu     (214)498-5472    Web Link    Nucleus Accumbens, Cocaine, Nornicotine, Self Administration, Cyclic AMP Response Element-Binding Protein, Reward, Nicotine, Prefrontal Cortex    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   Our current research is focused on the molecular mechanisms underlying the protective addiction and depression phenotype. We have already identified the transcription factor cAMP response-element binding protein (CREB) as one major mechanism in the EC phenotype. We have shown that we can reproduce the EC phenotype in normal pair-housed animals simply by blocking CREB function in the nucleus accumbens shell using novel viral vectors. However, CREB itself is only a transcription factor, meaning that it can only be a distal mechanism. Our future plans are to utilize well-established genomic expression profiling techniques in EC and IC rats to identify CREB target genes as proximal mechanisms mediating the EC phenotype. Once identified, additional viral vectors will be constructed to validate the role of these CREB target genes in mediating the protective EC phenotype. The overall goal of the project is to identify new mechanisms of resistance to addiction and depression to target for treatment as well as prevention of addiction and depression.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia GCC Cluster for Alcohol and Addiction Research GCC Mental Health Research Cluster Gulf Coast Cluster for Translational Addiction Science Junior Faculty Network  Appointments Title Department / School Institution Associate Professor Pharmacology and Toxicology UT Medical Branch at Galveston

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