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Faculty Profile Last Modified Time: 04:51:16 PM Thu, 11 Jul 2024   Contact Information Alemayehu Gorfe Associated Profiles  Professor, Integrative Biology & Pharmacology, UT Medical School, UT Health Science Center at Houston   Medical School Building, Room No.: 4.108    alemayehu.g.abebe@uth.tmc.edu     713.500.7538    Web Link    Lab Webpage    Ras Proteins, Molecular Dynamics Simulation, Membranes, Lipids, Molecular Dynamics, Cell Membrane, Computer Simulation    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   A major interest of our lab is to understand the thermodynamic principles of specificity in cell signaling and molecular transport by means of computational and theoretical techniques. The advent of petaflop computational resources and the fast-paced progress in coarse-grained modeling create unprecedented opportunities for simulating processes that span a vast range of time and length scales, such as cell signaling and molecular transport. These computational studies will allow us to investigate normal and aberrant properties of protein-protein and protein-membrane complexes in atomic detail. Other areas of interest include the basis of allosteric communication in signaling complexes, enzyme catalysis, molecular recognition and drug design. We develop and apply a variety of computational techniques, including classical and advanced molecular and Brownian dynamics simulations, structural bioinformatics, binding free energy calculations and related methods. Results from these studies will be the engines of new concepts and hypotheses to drive discovery efforts and experimental work. Current projects include the spatiotemporal membrane organization of Ras proteins and their reaction partners, the driving forces for the membrane translocation of positively charged proteins and peptides, identification of novel allosteric sites in proteins and characterization of the communication between those sites. These projects are carried out in close collaboration with experimental labs.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Training Grants Houston Area Molecular Biophysics Training Program Computational Cancer Biology Training Program Training Interdisciplinary Pharmacological Scientists  Research Consortia GCC Cluster for Cellular and Molecular Biophysics  Training Grants The Cancer Therapeutics Training Program (CTTP)  Appointments Title Department / School Institution Professor Integrative Biology & Pharmacology UT Health Science Center Houston

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