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Faculty Profile Last Modified Time: 07:25:06 AM Wed, 1 Apr 2020   Contact Information Geoffrey Bartholomeusz Associated Profiles  Associate Professor, Experimental Therapeutics, Cancer Medicine, UT MD Anderson Cancer Center   MDA 4SCRB4.1037, Room No.: Unit 1950    gbarthol@mdanderson.org     713.792.4158    Lab Webpage    Neoplasms, Schizosaccharomyces, Cells, P21-Activated Kinases, Small Interfering RNA, Karyopherins, Ovarian Neoplasms, Apoptosis    Associated Profiles Research and Expertise Affiliations Appointments  Research and Expertise Research Interests   Our primary research interests lie in improving therapeutic options by providing target driven therapy that is less toxic than conventional therapies and to help reduce mortality for patients with very aggressive forms of breast cancer. The research in our lab is focused on defining the biological and molecular effects of signaling pathways in breast cancer, with emphasis on triple-negative breast cancer (TNBC) metastasis. In particular, we have a strong interest in the role of the MAPK-pathway and inhibitors of this pathway, with emphasis on determining the factors involved in the mechanism of resistance of MAPK-directed therapy. We use a combination of genomic, proteomic, and siRNA approaches to define the role of these kinases in TNBC tumor progression. Our long-term goal is to develop a research program focused on (1) translating preclinical laboratory findings to novel investigator-initiated clinical trials and (2) identifying additional molecules to be targeted for therapy and biomarker development in TNBC.  Publications/Creative Works Click here to search for this faculty member's publications on PubMed.  Affiliations  Research Consortia John S. Dunn GCC for Chemical Genomics  Appointments Title Department / School Institution Associate Professor Experimental Therapeutics UT MD Anderson Cancer Center

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